Talk:Adderall/Archive 3

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Video Talk:Adderall/Archive 3

Grossly Unverified Claims

This article's most bold and significant statement regarding the drug's benefits for mood and lifestyle has absolutely no supporting references: "Adderall is widely reported to increase alertness, increase libido, increase concentration and overall cognitive performance, and, in general, improve mood, while decreasing user fatigue."

In addition the effects listed have indication as to how longlasting they are i.e. they may be short lived, and produce a withdrawl effect worse then their benefits. Also, it uses overly broad and unscientific phrases such as 'widely reported' and 'in general' with no supporting data. This unbalanced view, focusing on possible drug advantages may lead to false conclusions being made on this drug's efficacy in favour of any pharmaceutical company promoting it. Such bias would appear unacceptable and therefore this article needs ammendment.

Thomas.b.mole (talk) 15:33, 18 February 2011 (UTC)

Maps Talk:Adderall/Archive 3

Claims of different activity of the racemic mixture of dextroamphetamine salts

I believe the claims that the following chemicals have different half-lifes is untrue and used for marketing purposes. Please add a proper citation if I am mistaken. Thanks!

• 1/4 dextroamphetamine saccharate
• 1/4 dextroamphetamine sulfate
• 1/4 (racemic dextro/levo-amphetamine) aspartate monohydrate
• 1/4 (racemic dextro/levo-amphetamine) sulfate

Jatlas (talk) 18:27, 28 August 2009 (UTC) Going to relocate this information to discussion since I believe it is untrue. Jatlas (talk) 18:11, 2 September 2009 (UTC)

These four salts are metabolized at different rates and possess diverse half lives, therefore resulting in a less dramatic onset and termination of therapeutic action, as compared to single-salt amphetamine preparations. The average elimination half-life in adults for dextroamphetamine and levoamphetamine is 10 hours and 13 hours respectively.

I believe this is true information actually. I know it sounds like some marketing mumbo-jumbo but the different salts are contained in special beads. Some of the beads are designed to dissolve immediately, while others are time-released and dissolve in about 4 hours. I found a source to back this up: [[1]]. This is the basis of most extended-release drugs that need to maintain a therapeutic blood plasma concentration throughout the day, especially if the drugs half-life would not normally allow it to last an entire day.

A drug like amphetamine tends to produce undesirable effects/side effects when its blood plasma concentration is rapidly increased or decreased (especially the latter) and the formulation attempts to ensure smooth onset and smooth elimination of the effects. I'm going to go ahead and replace the information you removed because I think it really adds to the quality of the article and that source I linked proves what you took exception to or had skepticism about. -Novaprospekt (talk) 01:18, 28 March 2010 (UTC)

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Influence exersized by drug companies on this entry

Does anybody else get the strange notion that this article has been written by a PR executive at a drug company? There is very little talk about the side effects of the drug, and all negative claims are vigorously fought back by quoting questionable research papers. This is phreaking amphetamine for heavens sake - a class A drug - it WILL mess up your head if you use it for any prolonged time period. --Preceding unsigned comment added by 212.71.90.143 (talk) 19:24, 3 September 2009 (UTC)

You're complaining about POV while being POV yourself? C6541 (T<->C) 20:06, 3 September 2009 (UTC)

I will say adderall messed my heart up bad. I was a kid when they placed me on it. Now my heart fluters and my blood pressure is unstable. My blood pressure on average is 160/100 and my pulse is 120 when i just walk up the stairs. This substance should be band because its no better than its illegal bother meth! --Preceding unsigned comment added by 99.188.105.105 (talk) 05:21, 7 September 2009 (UTC)

One, methamphetamine is not an illegal drug, it is a prescription drug. Two, this is not a forum for general discussion. C6541 (T<->C) 07:02, 7 September 2009 (UTC)

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Citation needed for neutral viewpoint

Given that persons with ADHD are more likely to engage in risky or dangerous behavior, it has been suggested that stimulant medications for persons with ADHD may actually result in lower incidence of premature death.[37] --JaysonRL (talk) 06:50, 12 November 2009 (UTC)

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Changes in Behavior

I have collapsed this discussion per talk page guidelines. Papillonderecherche (talk) 20:22, 27 March 2013 (UTC)

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Availability outside the US

Could someone add information about the availability of Adderall outside the US? It's hard to track down this information. It isn't in the BNF or MIMS. Dexamfetamine sulphate is but not the combination described here. Njál (talk) 23:15, 5 June 2010 (UTC)

About this question: In a recent documentary shown on Arte (a french - german TV channel) called Les enfants et les psychotropes, Adderall was not mentioned at all. Most curious. The name Ritalin was mentioned many times. A big part of the filming had been done in the USA. Furthermore the film focused on a Boston hospital as the starting point of the expanding use of amfetamine treatment of children with Bipolar disorder or ADHD. But not a word about Adderall. The dialogues were translated, of course, and it is possible that the name of Adderall had been translated into Ritalin. --86.201.64.241 (talk) 15:38, 9 October 2010 (UTC)

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Adderall, Effect on person with Charcot-Marie-Tooth disease

My daughter has been prescribed Adderall for ADHD. I am concerned about any negative effect that may be known for the use of this drug on females with Charcot-Marie-Tooth disease/Type II. Has the use of Adderall by this group been studied? If so, where may I find the information?Zoraidalyle (talk) 00:21, 17 June 2010 (UTC)

adderall XR 30 mg

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Libido

Several people have mentioned that drugs of this type should increase libido, but the reference says only "Impotence, changes in libido" which makes it seem like it decreases. Anyone have a better citation for this? A13ean (talk) 03:27, 27 August 2010 (UTC)

• It's an amphetamine. As such, its side effects go both ways, sometimes killing libido, and sometimes boosting it. --Preceding unsigned comment added by 67.169.50.167 (talk) 05:48, 7 April 2011 (UTC)

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Brain's "preference" for Adderol isomers

There is a sentence in the article under "Mechanisms of action" that states: "Although it seems the human brain has a preference for dextroamphetamine over levoamphetamine...". I think should be changed since brains don't have a bias for drugs. Richard?Decal (talk) 18:07, 16 October 2010 (UTC)

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File:Adderall 30 mg.jpg Nominated for speedy Deletion

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That's...disconcerting.

From the opening paragraph: "It is thought to work by..." Well, that's disconcerting, you'd think we'd like to know how it works before stuffing our brains with it. 95.209.83.221 (talk) 12:15, 27 June 2011 (UTC)

Well take a look at every pharmaceutical page. Most psychoactive medications arent distributed by individuals with DIVINE KNOWLEDGE on the workings of the drug.-Datahivemind (talk) 16:18, 1 November 2011 (UTC)

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Question about mg's

I just wanted to know what mg. they come in? I know they come in 20 and 30./// but what else? -- Preceding unsigned comment added by 72.154.18.171 (talk) 04:28, 10 February 2012 (UTC)

Hello. Wikipedia is not a forum. Consult a doctor. 108.72.62.226 (talk) 16:02, 24 March 2012 (UTC)

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No section on recreational use?

How come this drug, which has high rates of abuse as it is amphetamine (one only need to look at several drug forums, studies, Erowid, etc.), has no section on its use as a recreational drug? Methamphetamine is almost completely devoted to its use as a recreational drug despite it too being used for ADHD (Desoxyn). I'm thinking I should add a section on its use as a stimulant for recreation. As it stands it smacks of a certain "its a perfectly legitimate drug with no problems" POV. C6541 (T<->C) 02:07, 20 April 2012 (UTC)

I added a small section regarding its recreational use. I hope to expand upon it later. C6541 (T<->C) 02:35, 20 April 2012 (UTC)

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No Mention of Product Shortage in the market

Hi. I didn't notice any mention of the current, ongoing, and prolonged shortage of Adderall in the market. I'm in Atlanta and I have a friend with narcalepsy. I haven't seen her in a while, she's probably sleeping, but I went all over town one day with her and we couldn't find Aderall anywhere. 24.126.238.179 (talk) 13:56, 1 June 2012 (UTC)

I agree with the preceding post. I am attempting to add this section. Please correct/improve as you more experienced editors see fit. Papillonderecherche (talk) 20:51, 4 January 2013 (UTC)

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Recent revert

I've recently reverted a couple edits by User:Skullballoons here. I don't believe that these edits are correct but I might be wrong. My understanding is that Adderall is a racemic mixure of dextro and levo ampetamine. Also, I'm pretty sure it is available in Canada. If I'm incorrect I'd appreciate it if the user would present sourcing that contradicts our current article (which I'm assuming the sources support having read them about a year ago - it's possible they've changed but I'm a bit too busy to scrutinize them at the moment). SÆdon^talk 21:24, 21 June 2012 (UTC)

Adderall is not racemic, it's a mix of dextroamphetamine and racemic amphetamine coming out to 3/4 dextro and 1/4 levo. However I have heard nothing about it being banned in Canada and there are no citations. I'm assuming good faith, but it appears skullballoons is getting into a revert war. C6541 (T<->C) 23:07, 21 June 2012 (UTC)

Eh scratch that, amphetamine salts were indeed re-scheduled and placed to schedule I in Canada. C6541 (T<->C) 23:11, 21 June 2012 (UTC)

Saedon, you are correct; Adderall XR is still widely available in Canada. It was reclassified to a class 1 drug, but this does not mean the same thing as a schedule I drug in the USA. Class 1 drugs in Canada still may have recognized medical uses (such as Oxycodone, which also appears in this list) but criminal offences involving these drugs carry stronger penalties and jail times versus lower classes.DangerGrouse (talk) 23:28, 31 July 2012 (UTC)

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Legality in Canada

Editor: 12.167.100.194 reverted the edit that I made, and indicated that Adderall is illegal in Canada. This is not the case; it is still legal. Under the new Safe Streets and Communities Act, Amphetamines and derivatives have been reclassified to schedule 1. This does NOT automatically make the substance illegal; it simply means there are harsher penalties for illegal activities such as trafficking and manufacture. Adderall still exists as an active medication in the Health Canada database. I will wait to see if there are any objections; otherwise I will go ahead and make the change. DangerGrouse (talk) 18:43, 18 November 2012 (UTC)

Too Technical technical to understand?

The too technical issue only exists in one section: "Mechanism of Action." An effective rewrite of that section would justify a removal of "too technical" tag in my opinion.

The rest of article from a clarity standpoint is fine. Ranger2000 (talk) 19:31, 28 November 2012 (UTC)

I'm not seeing how it's too technical, if anything it's a simplistic explanation of the MOA, that section could use more cites rather than a rewrite. But by all means be bold. C6541 (Talk <-> Contribs) 19:49, 28 November 2012 (UTC)

The "Mechanism of Action" section could be simplified a little by reducing the styles for naming optically active forms from 3 to 1. The introduction of R and S is not needed; it's a convention used mainly by organic chemists because it is describes absolute chiral configuration. If d- and l- are used, they should be defined as meaning dextro- and levo-. They were not defined anywhere in the article. D- and L- are often used in the article, and should not be used to mean d- and l-. D- and L-, properly rendered in small caps, are a chemist's convention for relating absolute chiral configuration to glyceraldehyde. Drbillellis 01:06, 4 December 2012 (UTC) -- Preceding unsigned comment added by Drbillellis (talk o contribs)

Amphetamine neurotoxicity

Why is there no mention in this article about amphetamine neurotoxictiy (relating to VMAT2)? Seems like it is important information. 80.98.57.37 (talk) 17:56, 25 December 2012 (UTC)

Neutrality

This is yet another drug-related article that is under-developed and full of weasel words and POV. A lot of it seems to be added bit-by-bit by people on the anti-ADD-medication bandwagon, and the page wasn't sufficiently policed to catch it all. I'll try to clean it up when I have the time, any help is greatly appreciated. Exercisephys (talk) 20:28, 19 May 2013 (UTC)

Agreed. -- Preceding unsigned comment added by 121.72.168.141 (talk) 11:32, 5 June 2013 (UTC)

Title change from Adderall

I changed the title to be like other drug pages. Some editors raised questions, so I checked the policies. It seems consistent with the policy that I did it... Cantaloupe2 (talk) 00:22, 20 May 2013 (UTC)

discussion that I posted on Patraarchan47's user talk;

The guideline (there is no policy governing article names) is that the title of small molecule drugs should be named after International Nonproprietary Name (INN). As far as I am aware, no INN has been assigned to Adderal. "Amphetamine mixed salts" is not an INN. It is a generic but non-specific description of Adderal. A specific generic name for Adderal is "dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate and amphetamine sulfate" which is much too long for an article name. The guideline does allow the use of brand names where INN or generic name is not available. Hence I think the name of this article should be changed back to Adderal. Boghog (talk) 21:26, 25 May 2013 (UTC)

Since we already have separate articles on racemic amphetamine and optically pure dextroamphetamine, the scope of this article should be restricted to dextroamphetamine enriched amphetamine. So an alternative title for this article is dextroamphetamine enriched amphetamine. In my opinion, that title would be preferable to the present article title since it more precisely defines the scope of this article. Boghog (talk) 22:03, 25 May 2013 (UTC)

Personally, I think this article should either be retitled Adderall or greatly reduced in size and redirect to the amphetamine and dextroamphetamine pages. It seems highly redundant to have a 3rd page on both. Furthermore, as far as I know, there's nothing preventing new mixed-amphetamine drugs from entering the market; in that event, the title of this page would simply cause confusion. As already mentioned, the new name of this page is definitely NOT consistent with the policy, which says "Drugs--The International Nonproprietary Name (INN). Most biologics, including vaccines, do not have INN or other generic names, so the brand name is used instead." Seppi333 (talk) 17:41, 11 June 2013 (UTC)

As I stated above, I support changing the name back to Adderall. Regardless of what the article is called, I disagree that the contents of this article are redundant. Dextroamphetamine and amphetamine have significantly different pharmacological effects from each other and a fixed 3:1 mixture (as found in Adderall) would have effects that differ somewhat from either of the two ingredients. Furthermore Adderall and its generics are fairly widely prescribed. Boghog (talk) 21:03, 11 June 2013 (UTC)

That's a moot point if this page is merged with Obetrol. Besides, I don't see how what's written on this page wouldn't be a subset of the information contained on the 2 aforementioned articles. As you said, adderall is 75% dextroamphetamine and 25% levoamphetamine, which would make it 50% amphetamine and 50% dextroamphetamine. Insofar as I can tell (ie, after spending an hour trying to find a single research paper to say otherwise), while levo- and dextro-amphetamine are different compounds, the neuropsychopharmacological profiles relating to catecholamines are roughly the same (each has effects on TAAR1, VMAT2, MAO-?, DAT, NET, etc. with possibly different intensities). The research I've read just differentiates the two by their relative effects on dopamine vs norepi and behavioral modification in ADHD (which is simply reflective of the variance in dopamine/norepi). That said, there doesn't seem to be that much research on pure levoamphetamine.

In any event, there already is redundancy on these pages because I ended up deleting identical mis-citations on 2 of these pages and removing/adding identical information (literally, just copy/paste) on all 3 of these pages today. Seppi333 (talk) 01:58, 12 June 2013 (UTC)

As argued below, below, the original formulation of Obetrol contains a mixture of methamphetamine and amphetamine and hence is a different drug than Adderall. Therefore I believe Obetrol (or at least the section on the original formulation) should not be merged with Adderall.

Roughly the same is not exactly the same. The two enantiomers do have somewhat different pharmacokinetics and pharmacodynamics. Redundancy can be reduced as you have already done through copyedit. As the topics partially overlap, some redundancy between the articles cannot be avoided, but this is not necessarily a bad thing. Finally the particular formulation of mixed salts contained in Adderall is widely prescribed and this is reason alone to have a separate article on Adderall. Boghog (talk) 06:14, 12 June 2013 (UTC)

I really can't find an authoritative source on the differences in pharmacodynamics. IMO, pharmacokinetic differences aren't relevant enough to merit having separate pages on the enantiomers. I'd frankly rather see the pages on levo, dextro, and amph merged instead than this one pared down and linked to them. The information on dextro and levo could just as well be mentioned in sections in the amph page. I just think it's a bit excessive to have this many pages on the same topic. In any event, I'm well aware of how widely adderall is prescribed in the US compared to other psychostimulants; I've even contributed to that number for over a decade. Seppi333 (talk) 02:30, 15 June 2013 (UTC)

Amphetamine salts

I'm on the fence on this one. Let's say I say "sodium salts". It would be a general page of various salts of sodium, as opposed to say.. a product of combination of salts marketed as "combo" as accepted in industry. So, "amphetamine salts" while "amphetamine salts combo" specifically refers to single entity pharmaceutical product. Cantaloupe2 (talk) 23:08, 19 May 2013 (UTC)

Adding comment to this...

update, I checked the policies and I am doing this right for them most part. One difficult is that proper INN would be the list of all four components and the US non-proprietary name would be "Mixed salts of a single-entity amphetamine product" per FDA hosted PDF document Either ways, it would be too long. "Amphetamine combos" is what it pops up under generic name on pharmacy sites and I'm inclined to keep it as what it is now if other editors are ok with it. Cantaloupe2 (talk) 00:13, 20 May 2013 (UTC)

I agree with the move in principle of the naming conventions but I disagree with the particular target. "Combo" is a colloquial abbreviation and is commonly used in short hand pharmacology but it is not titular (to use a very casual version of the word). I would suggest instead Mixed amphetamine salts, or probably most concisely Racemic amphetamine salts as my understanding is that all combinations under the purview of this article will be racemic (and those which aren't are not within its scope as far as I can tell). Alternatively, since "racemic" implies salts anyway, Racemic amphetamine might be even better. Additionally, if we're going by the bottle sitting in front of me, it's only Amphetamine salts. Regardless, I think we should drop "combo." Sædon^talk 08:58, 20 May 2013 (UTC)

I agree. "Combo" is too informal for a serious encyclopedia. "Racemic" seems unnecessarily technical, and maybe not entirely correct. Mixed amphetamine salts might be a winner even though slightly vague. It's nonproprietary and correct, at least. Is there a way to word it that suggests that it's a very specific drug? What do doctors write on prescriptions? --Ben Kovitz (talk) 14:38, 20 May 2013 (UTC)

At least in the states, the prescriptions I've seen just say "amphetamine salts." Exercisephys (talk) 15:26, 20 May 2013 (UTC)

It is used in official labeling by some. See this. How about "amphetamine mixed salts (medication}" or "amphetamines mixture (medication)" much like Lithium_(medication)? Since INN for this would be unusually long, I'm not sure how it is best done..Cantaloupe2 (talk) 21:57, 21 May 2013 (UTC)

"amphetamine mixed salts (medication)" is definitely the better of those two options. Exercisephys (talk) 22:09, 21 May 2013 (UTC)

+----------------------------------------------------------------------------------------------------+ I do not think "amphetamine mixed salts" is a good name since it is imprecise. dextroamphetamine and amphetamine would be better or perhaps "amphetamine and dextroamphetamine mixed salts". Adderall and Biphetamine are brand names is a brand name of this specific combination of amphetamine and dextroamphetamine. Furthermore the current lead is incorrect since it doesn't mention dextroamphetamine. Boghog (talk) 06:35, 24 May 2013 (UTC)

Additionally, Amphetamine mixed salts does not seem to be grammatically correct (I read it as "Amphetamine, mixed salts"). Should it not instead be Mixed amphetamine salts? However, if we want to use the prescription label it should just be Amphetamine salts - though non-specific, it is likely the most true to reliable sources. Sædon^talk 09:51, 24 May 2013 (UTC)

A consideration that was given in titling is to place amphetamine as the first word so it helps user searching it by bringing it up in suggestions. Cantaloupe2 (talk) 19:47, 24 May 2013 (UTC)

I think you are not understanding that "isomers of amphetamine" is inclusive of l-amphetamine and d-amphetamine. You also misunderstood what Biphetamine is. Biphetamine is d,l-amphetamine sulfate in 50/50. Adderall involves three different salts and enantiomeric ratios are different. Cantaloupe2 (talk) 19:47, 24 May 2013 (UTC)

What kind of isomer? Stereoisomer or regioisomer? The lead needs to be more precise. Biphetamine is a side issue and in any case is a discontinued drug that is no longer available. Boghog (talk) 20:10, 24 May 2013 (UTC)

Also "amphetamine and dextroamphetamine mixed salts" needs to be included as a synonym in the lead because it is frequently referred to as that. Boghog (talk) 20:19, 24 May 2013 (UTC)

Where are you getting that drugs that are no longer commercially available become a side issue in pharmacology project? Can you cite policies? Cantaloupe2 (talk) 22:42, 24 May 2013 (UTC)

In the context of this immediate discussion, it is a side issue. I never stated that discontinued drugs are unimportant within the pharmacology project. Quite to the contrary, discontinued and failed drugs can teach us a lot and are appropriate subjects of Wikipedia articles. Once a drug, always a drug. Boghog (talk) 23:48, 24 May 2013 (UTC)

Racemic mixtures of amphetamine such as Biphetamine fall within the scope of the amphetamine article, not this one. Optically pure amphetamines fall within the scope of the dextroamphetamine and levoamphetamine articles, and again, not this article. The scope of this article is amphetamine that has been enriched with dextroamphetamine (1 < d/l ratio < 0.5). By far, the most commonly available form is Aderall and Aderall generics all of which have a 3:1 d/l ratio. Are there any commercially available forms of dextroamphetamine enriched amphetamine (present or past) that have an enantiomeric ratio that differ from this? Boghog (talk) 21:55, 25 May 2013 (UTC)

Google searches on "adderall" no longer find this page. Seppi333 (talk) 08:36, 16 June 2013 (UTC)

The Google search results (or lack thereof) is a very strong reason to change the name back to Adderall. Making it more difficult for the general public to find this article is bad thing. Furthermore, there is ample precedence for having separate Wikipedia articles for widely prescribed brands of drugs (e.g., Advil, NyQuil, Sudafed, Tylenol, etc.) in addition to the articles on the corresponding generic equivalents. Adderall certainly qualifies as a widely prescribed drug. Boghog (talk) 09:11, 16 June 2013 (UTC)

History section

The history section here is a little iffy, depending on how we define the term "amphetamine salts combo." It may only mean the specific formula used in Adderall and its generics; current medical literature assumes this is the case. However, the current history section contradicts this, presenting other combinations of amphetamine salts as "amphetamine salts combos" as well. If the history section stays, the combo section of the drug info box may have to go. Exercisephys (talk) 01:30, 20 May 2013 (UTC)

This might highlight the need for an article about Adderall specifically, and keep this one a general, perhaps more technical, discussion. The truth is, given recent controversy surrounding Adderall specifically, removing the Adderall article serves the makers of the product rather than the WIkipedia reader, imo. petrarchan47tc 02:28, 20 May 2013 (UTC)

I don't think that it's worth worrying about what effect we're having, positive or negative, on the manufacturers of Adderall. The fact of the matter is that Adderall is a brand name version of amphetamine salts, which is a pharmaceutical. That's how it's seen in the medical and pharmaceutical communities these days. If you buy generic amphetamine salts in a pharmacy it has a composition identical to Adderall and is labeled "amphetamine salts" (or "amphetamine salts combo"). Exercisephys (talk) 02:52, 20 May 2013 (UTC)

...I just saw the comment about policy from Canteloupe. Prozac redirects to Fluoxetine, with sections for Adverse effects, subsections: Discontinuation syndrome, Suicide, Violence, Interactions; and "Other brand names" are dealt with at the end. The "Popular culture" is entirely about Prozac, specifically. It doesn't seem to be a problem, the article reads well. It might be a good example to follow here. petrarchan47tc 02:49, 20 May 2013 (UTC)

Sounds good. That information at the beginning of the History section is interesting and notable though, we should move it to the amphetamine article if we're going to remove it. Exercisephys (talk) 02:53, 20 May 2013 (UTC)

I was just about to do this move, but it turns out the History section of the amphetamine article needs significant cleaning up too. It has a whole paragraph about methamphetamine. I'll get to it tomorrow morning if no one else beats me to it. Exercisephys (talk) 02:57, 20 May 2013 (UTC)

Now I am wondering even more about whether this could be a POV fork. The Prozac article, as I mentioned, is very general except for the "In popular culture", which was 100% about Prozac specifically. But when I changed the title to reflect this information ("Prozac in popular culture"), my suspicion that information is being obfuscated (the antithesis of encyclopedic) was only strengthened in this revert. Any thoughts? petrarchan47tc 01:35, 21 May 2013 (UTC)

I don't know what the scientifically accepted definition would be, but that's the general direction. The aim of wiki is to go for globally relevant contents and not just in the context of anglophone culture. I expect region specific legal definition varies form scientific definition. I'm looking to get rid of the wording "single entity" once I find something else to replace it with. It appears arbitrarily defined for legal definition sake by the US government. Adderall and its predecessor are the ones I have any fundamental knowledge for me to start research from so that's where I am starting. I can't tell for sure if there are any other formulas containing multiple isomers and/or salts of amphetamine derivatives.. and even if there is, how far can we extend as "derivative" ? It doesn't have to represent one very specific standardized preparation though. Cantaloupe2 (talk) 06:39, 20 May 2013 (UTC)

Since the two enantiomers of amphetamine are both pharmacologically active but with somewhat different effects, the exact ratio of enantiomers that the drug contains is significant. The enantiomeric ratio is not just a legal distinction. It also has pharmacological consequences. Boghog (talk) 22:02, 24 May 2013 (UTC)

Aderal is a stereochemically enriched mixture of amphetamine salts with a specific enantiomeric excess (the "drug substance", FDA definition) formulated in a specific way (to produce a "drug product") that was developed by the drug sponsor. Furthermore Aderal is an approved drug. Generic competitors that wish to obtain marketing approval under a Abbreviated New Drug Application must use the same drug substance (since both enantiomers are active with some what different effects, the generic must contain the same enantiomeric excess as contained in Aderal) and show bioequivalence with the original formulation. Hence this specific stereochemically enriched mixture was not defined by the US government, but rather the drug sponsor. Boghog (talk) 20:47, 24 May 2013 (UTC)

The non-proprietary name that the FDA has assigned to Adderall, Mixed Salts of a Single Entity Amphetamine Product, is very instructive. More specifically, the name contains the word "product". Furthermore according to FDA definitions, a drug product is a specific formulation of a drug substance. This implies that Adderall generics, at least in the US, must have an identical formulation to Adderall. Boghog (talk) 23:03, 24 May 2013 (UTC)

Correction to what I wrote above. There are at least two formulations of Adderall deveoped by Rexar/Richwood/Shire, so there obviously can be more than one formulation of Adderall generics. Boghog (talk) 22:38, 25 May 2013 (UTC)

"Pharmacology" vs. "Mechanisms of Action"

Can anyone tell me how these two sections differ? This article has both of them, as does amphetamine, but the distinction seems really dubious. Exercisephys (talk) 03:16, 23 May 2013 (UTC)

I am planning on combining them at one point. It's still a work in progress. It was a HUGE mess before I started working on it. I've put a few hours into this and still not done. I've been scrutinizing every bit and whenever I come across something that looks opinionated, I go back to sources and validate if the references indeed support that stance. Unfortunately, it is badly contaminated with interpretive and personal value claims by various editors who worked on this article. I'm using the article Aspirin as guidance. It is a good article in pharmacology project.

Obetrol Merge

Intro confusing

This is confusing:

Amphetamine mixed salts, also known as amphetamine and dextroamphetamine mixed salts, amphetamine salt combo, amphetamine salts and under the brand name Adderall, is a pharmaceutical drug consisting of a mixture of salts and enantiomers[1] of the stimulant amphetamine. As of 2013, there is a single accepted formulation, which contains a 3:1 ratio of dextroamphetamine (the dextrorotary or "right-handed" enantiomer) to levoamphetamine (the levorotary or "left-handed" enantiomer)

First, it's hard to read. I guess the phrase "of the stimulant amphetamine" is meant to modify the noun enantiomers and also the noun salts? We cannot be sure. I would edit it, but I dont know: salts of, and enantiomers[1] of, the stimulant amphetamine. I am going to at least put "also known as..." in parenthesis to divide it from the definition.

But after getting through, I still have the following questions: It is a "a mixture of salts and enantiomers[1] of the stimulant amphetamine." It is salts + enantiomers... pretty clear. But there is "a single accepted formulation, which contains a 3:1 ratio of dextroamphetamine (the dextrorotary or "right-handed" enantiomer) to levoamphetamine (the levorotary or "left-handed" enantiomer)" Um, now it is made of dextroamphetamine + levoamphetamine. Okay, how exactly is that the same thing as salts + enantiomers? Or are you saying it is salts + enantiomers, where the enantiomers are then made of dextroamphetamine + levoamphetamine? Or maybe the levoamphetamine is the salts part and the dectroamphetamine is the enantiomers part? Finally, all other sites I visit say adderall is a simple combo of amphetamine plus dextroamphetamine. How do I reconcile that with the above? Are they wrong, or is that somehow equivalent to what we are writing? 108.65.1.41 (talk) 05:43, 27 May 2013 (UTC)me

A previous version read:

Amphetamine mixed salts (also known as amphetamine and dextroamphetamine mixed salts or amphetamine salt combo or amphetamine salts and under the brand name Adderall) is a pharmaceutical drug containing of one or more salts of amphetamine that is enriched in the "right-handed" dextroamphetamine form of amphetamine. The most commonly available form (including Adderall and Adderall generics) has a 3:1 ratio of dextroamphetamine [right-handed] to levoamphetamine [left-handed].

Racemic amphetamine is a 1:1 mixture of dextroamphetamine and levoamphetamine. Aderall in turn is a 1:1 mixture of amphetamine and dextroamphetamine. Hence Aderall is one part dextroamphetamine and one part levoamphetamine from the amphetamine portion of the medication and 2 parts dextroamphetamine from the dextroamphetamine portion of the medication. The net result is that Adderall contains three parts dextroamphetamine to one part levoamphetamine. Furthermore the amphetamine and dextroamphetamine contained in Adderall are in the form of salts instead of the free base. Boghog (talk) 06:24, 27 May 2013 (UTC)

A simpler alternative is simply to say the drug is a combination of amphetamine and dextroamphetamine:

Amphetamine mixed salts, also known as amphetamine and dextroamphetamine mixed salts or amphetamine salt combo or amphetamine salts and under the brand name Adderall, is a pharmaceutical drug consisting of a mixture of salts of racemic amphetamine and optically pure dextroamphetamine.

Boghog (talk) 10:40, 27 May 2013 (UTC)

Per your suggestion, the lead has been edited to first simply state that "amphetamine mixed salts" are a "mixture of amphetamine and dextroamphetamine salts" and then later specify the ratio of the stereoisomers. I hope the lead is now clearer and at the same time retains accuracy. Boghog (talk) 19:41, 27 May 2013 (UTC)

Popular misconceptions about stimulant medications and ADHD.

I added my previous statement clearing up the misconception that stimulant drugs affect individuals with ADHD differently than someone who does not have ADHD. "Contrary to popular misconception, the effects of stimulant drugs (including amphetamine salts) on individuals with ADHD is not "paradoxical" as the same increase in focus and motivation, as well as the same suppression of motor activity is seen in individuals who do not have ADHD. This leads to the conclusion that the presence of ADHD does not change the pharmacological action of stimulant medications in anyway."

I feel very passionately about this subject and I hope this can now be put to rest.

This is definitely an improvement, but per WP:MEDRS, secondary sources are needed to back up medical claims. This secondary source looks relevant, but I do not have access to the full text to be certain. Boghog (talk) 10:13, 2 June 2013 (UTC)

Whoops, I improperly formated the ref tags the first time. Thanks for fixing that for me. SwampFox556 (talk) 5:26, 2 June 2013 (UTC)

Removed claim about prevalence of abuse

I went through this cited reference. Here are two sentences from the source " The authors investigated illicit use of stimulant medications at a midwestern university." "Findings revealed that 17% of 179 surveyed men and 11% of 202 women reported illicit use of prescribed stimulant medication. "

The original prose I removed read "Amphetamine salts is widely used as a cognitive enhancer at universities." This is slippery slope synthesis. The source analyzed stimulants abuse at a university. The source doesn't advance the position "widely used at" multiple "universities" and a case study can't be extrapolated to make it generally applicable. Furthermore, this is regarding all stimulants, which is inclusive of methylphenidate and others. So, it is not specific enough to this article. Cantaloupe2 (talk) 09:53, 29 May 2013 (UTC)

Claim that Bupropion synergises with Amphetamine.

I am questioning this due the pharmacodynamic actions of Bupropion, as well as the pharmacodynamic actions of Amphetamine. The article states "Both bupropion and amphetamine have noradrenergic and dopaminergic activity. Possible augmentation/potentiation of effects. Bupropion has pro-convulsant properties that may be enhanced or cumulatively potentiated by amphetamine."

I know it says "Possible augmentation/potentiation" however, I'm questioning whether or not this is correct. According to the Wikipedia article on Bupropion - Bupropion exerts its reuptake inhibiting mechanism of action by binding to the Monoamine transporters, thus blocking them. Since a lot of Amphetamines stimulating effects are due to the fact that it reverses Monoamine transporters, I'm almost certain that Bupropion would dull effects felt from Amphetamine due to the fact that the transporters wouldn't outflow their respective neurotransmitters.

I am 95% certain this is the case and I was planning on adding that in the article, however, I don't know of any study that confirms this which is what stopped me. I am going to plan on looking, but since both of these are stated on Wikipedia, would I even have to? What I mean by that is, since we know Bupropion for sure exerts its action by binding to transporters, and we know for sure that medications that bind to Monoamine transporters stop both inflow and outflow of neurotransmitters, it seems pretty obvious to me that Bupropion would result in decreased effects felt by amphetamine and therefore wouldn't result in "potentiated pro-convulsive effects" but would rather be unaffected or even possibly lessened, due to the Bupropion.

Alternatively, does anyone know for sure if I am incorrect? SwampFox556 (talk) 08:31, 5 June 2013 (UTC)

We require verifiability through MEDRS in some cases and sometimes plain 'ol RS. Not absolute correctness. If multiple reliable sources disagree, we simply list them both and summarize and leave it at that. For something like this, it is expected to have supporting evidence in MEDRS rather than popular press. So, if cited references do not support this or they are not MEDRS, purge it. Cantaloupe2 (talk) 13:05, 5 June 2013 (UTC)

The pharmacological interaction between Bupropion and Amphetamine is mediated by the CYP2D6 liver enzyme and another unknown mechanism related to lowered seizure threshold. Bupropion is a strong inhibitor of CYP2D6 and amphetamine compounds are metabolized on CYP2D6 to weaker sympathomimetic compounds. As a result, hepatic metabolism of amphetamines along that pathway essentially ceases with concurrent bupropion usage. It has nothing to do with their neuropsychopharmacological profiles related to catecholamines. Seppi333 (talk) 16:45, 11 June 2013 (UTC)

Requested move

Abuse & performance-enhancing section

I've removed statements that I could not verify or were based on primary sources contradicted by secondary sources, and added citations where they were needed. I've added a good secondary source and removed the box flagging this section. I had to put in a link to the Wikipedia section on the UN Convention because the UN primary source had strangely difficult-to-link-to documents in it: I verified that this section of Wikipedia was right about MA salts, though. There were 3 sections to cover a small amount of issues and content, so I collapsed them into one. Hildabast (talk) 21:53, 20 June 2013 (UTC)

Use, prolonged use and withdrawal

I've removed an unreferenced statement about withdrawal, and included information from a secondary source on withdrawal. However, the prolonged use info that is there really needs quite a bit of work - I think it would be more useful if this addressed pharmaceutical use with normal doses separately from illicit use of MA. But I didn't have time to do the work on this. Hildabast (talk) 22:17, 20 June 2013 (UTC)

I added secondary sources on treatment and additional source of information on use, but only briefly summarized the results. Hildabast (talk) 22:44, 20 June 2013 (UTC)

Section on performance-enhancing

Source of the article : Wikipedia